RETURN TO SUPER GLISODIN HOME PAGE
RESEARCH ON SUPEROXIDE DISMUTASE
Mechanisms of inflammatory lung injury
Emphasis is on evaluating the role of free radicals in pulmonary oxidant injury and on evaluating changes in pulmonary structure/function caused by exposure to oxidants or proinflammatory mediators. I am investigating the hypothesis that extracellular superoxide dismutase plays a critical role in controlling inflammation in the lung. EC-SOD scavenges superoxide and is the primary antioxidant enzyme in lung extracellular spaces. In the absence of EC-SOD, superoxide can react with nitric oxide to form peroxynitrite which is a highly reactive pro-inflammatory radical. In the presence of EC-SOD nitric oxide is preserved and acts as the key immunomodulatory agent in the lung. This hypothesis is being tested in both cells and animals using genetically modified cells and transgenic or knock-out animals over- or underexpressing extracellular superoxide dismutase. Novel antioxidant mimetics are being developed and tested as new and potentially effective
Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med. 2003 Jun 15;167(12):1600-19. Review.
Bowler RP, Arcaroli J, Abraham E, Patel M, Chang LY, Crapo JD. Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Apr;284(4):L680-7. Epub 2003 Jan 10.
Chang LY, Subramaniam M, Yoder BA, Day BJ, Ellison MC, Sunday ME, Crapo JD. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2003 Jan 1;167(1):57-64.
Bowler RP, Crapo JD. Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol. 2002 Sep;110(3):349-56.
Chang LY, Crapo JD. Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic. Free Radic Biol Med. 2002 Aug 1;33(3):379-86.
Oxidative stress in airways: Role for extracellular superoxide dismutase
Disclaimer: The data on this site is provided for informational purposes only, and not meant to "substitute for the advice provided by your own physician or other medical professional", nor is it intended for "the diagnosis, treatment, cure, or prevention of any disease." We must also advise that you should "not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication," and "The FDA has not evaluated any statements on this site." The information on the web site has been obtained from the manufacturers of these products or the components thereof, scientific research and sources considered reputable in the specific area of discussion.