A Major Study and Human Trial 


Influence of an Orally Effective SOD on Hyperbaric Oxygen-related Cell Damage Free Radical Research, Volume 38 Number 9 (September 2004), pp. 927–932 



In a new study using a dramatic human model, where healthy volunteers are subjected to intense oxidative stress, GliSODin® was shown to protect against cellular DNA damage. These findings coincided with reduced blood isoprostane levels, another marker of oxidative stress. Interestingly, GliSODin® is the first to show this protective benefit in this model. Vitamin E, for example, did not pass this model. 



The double-blind randomized study was performed at the University Hospital in Ulm, Germany. It used a hyperbaric model for oxidative stress on nuclear DNA in vivo. The SOD in GliSODin is co-processed with gliadin protein by a patented process. Gliadin has been shown to both protect the melon SOD and increase its effectiveness. 



These findings support the body of evidence behind GliSODin® benefits. 



GliSODin® ability to promote SOD, Catalase & Glutathione peroxidase, the powerful cellular antioxidants produced by our bodies, clearly make this a desirable dietary supplement, as well as a powerful addition to antioxidant and anti-inflammatory formulations. 



From the study:


Influence of an Orally Effective SOD on Hyperbaric Oxygen-related Cell Damage, C. Muth, Y. Glenz, M. Klaus, P. Radermacher, Guenter Speit, X. Leverve. Free Radical Research, Number 9 (2004) 927–932.



"In a prospective, double-blind, randomised placebo controlled study, we tested the hypothesis that a new formulation consisting of wheat gliadin chemically combined with a vegetal (thus orally effective) preparation of superoxide dismutase (SOD) allows to prevent hyperbaric oxygen (HBO)-induced oxidative cell stress. Twenty healthy volunteers were exposed to 100% oxygen breathing at 2.5 ATA for a total of 60 min. DNA strand breaks (tail moments) were determined using the alkaline version of the comet assay. Whole blood concentrations of reduced (GSH) and oxidised (GSSG) glutathione and F2-isoprostanes, SOD, glutathione peroxidase (GPx) and catalase (Cat) activities and red cell malondialdehyde (MDA) content were determined. 



After HBO exposure the tail moment (p=.03) and isoprostane levels (p=.049) were significantly lower in the group that received the vegetal formulation. Neither SOD and Cat nor GSH and GSSG were significantly affected by this preparation or HBO exposure. By contrast, blood GPx activity, which tended to be lower in the SOD group already before the HBO exposure (p=.076); was significantly lower 



afterwards (p=.045).



We conclude that an orally effective SOD–wheat Gliadin mixture is able to protect against DNA damage, which coincided with reduced blood isoprostane levels, and may therefore be used as an antioxidant."