Influence Of An Orally Effective SOD
On Hyperbaric, Oxygen Related Cell Damage
Free Radical Research 38:9 (2004) pp. 927- 932
Extreme exercise is another model for induced oxidative stress. Several markers of this stress are serum total antioxidant status and plasma lactic acid. In a compelling study, healthy volunteers supplemented their diets with 1500 mcg of GliSODin® for four weeks. Prior to GliSODin® use, the volunteers participated in
strenuous exercise and baseline measurements of serum total antioxidant status, plasma lactate accumulation and several other markers were measured for each participant. After supplementation, the extreme exercise was repeated and the oxidative stress markers where measured once again. GliSODin® supplementation resulted in a significant change in oxidative status and a significant decrease in exercise-induced lactate release, suggesting the damage caused oxidative stress was significantly inhibited.
GliSODin® works by promoting our own, innate cellular protection. Our internal antioxidant defense system differs from “antioxidants” that are obtained from dietary sources.
The body’s antioxidant supply can be classified into two groups:
Dietary antioxidants, which are externally provided: certain foods are rich in antioxidant substances like vitamins (Vitamin C, Vitamin E and Vitamin A), minerals (Selenium, Zinc, Copper and Manganese) and other substances, including the polyphenols found in grapes and green tea. These external antioxidants contribute to the antioxidant reserve yet play a secondary role to the body’s own antioxidants
Enzymatic antioxidants, which are made by the body, thus internally provided: the internal antioxidant defense system includes Super Oxide Dismutase (SOD), Catalase and Glutathione Peroxidase, which are the first, and most powerful, line of defense against oxidative stress.
Among these enzymes, SOD plays the primary role. SOD transforms the most reactive, and therefore the most dangerous, free radicals– the Super Oxide radicals – into ions that are less reactive; these less reactive ions are then transformed by the two other enzymes. This transformation is called dismutation, thus its name Super Oxide Dismutase. SOD also “signals” other cells to produce more SOD, thus preparing the antioxidant defense system against free radical attack.