On Oxidative Stress Reduction 



Oxygen is the most important element for life. During its utilization by the human body, oxygen gives birth to very reactive forms called “free radicals”. Free radicals are destroyed by the natural defense systems termed “antioxidants”. 



The body’s antioxidant mechanisms can be classified into 2 groups: 



• Dietary antioxidants (exogenous): certain foods are rich in antioxidant substances like vitamins (Vitamin C, Vitamin E and Vitamin A or its precursor beta-carotene), minerals (Selenium, Zinc, Copper and Manganese) and other substances, including the polyphenols found in grapes and green tea. 



• Enzymatic antioxidants made by the body (endogenous): the three main enzymes are Super Oxide Dismutase (SOD), Catalase and Glutathi-one Peroxidase. 



Free radicals and/or chemical related compounds, when produced in excess, are responsible for cellular toxicity and contribute to the longterm development of most inflammatory-related diseases. In fact, the molecular and cellular activities of free radicals are highly dependent upon the threshold of production of these chemical entities.

Under "normal" conditions the potential excess production of free radicals is buffered by anti-oxidant enzymes and/or quenching molecules. 



The disturbance of the delicate equilibrium between oxidant and anti-oxidant molecules is mainly initiated by pathogens (virus, bacteria etc.) and/or antigens (nutritional products, allergens, vaccine etc.) and is regulated positively or negatively by various immune reactions (2,3). 



The majority of free radical actions can be divided in seven Immuno-Redox overlapping categories:

1. cytokine, growth factor, hormone and mediator action and secretion,
2. ion transport,

3. alteration of cell signaling,
4. transcription,
5. gene activation and/or repression,
6. alteration of mitochondrial functions, and cell death by apoptosis 



These observations led to the development of a large number of anti-oxidant products (nutrients and drugs). However, until now the development of these products has not been optimal for two main reasons. Previous products often had poor bioavailability, and the complexity of the dynamic equilibrium between free radicals and the related anti-oxidants has always been underestimated. 



In the mid-1950s, the proposed ‘free radical theory of aging’ postulated that the accumulation of damage caused by free radicals was the underlying mechanism by which organisms age. Oxidative stress is the harmful condition that occurs when there is an excess of free radicals, a decrease in antioxidant levels, or both. Strategies aimed at limiting and repairing the damage attributed to oxidative stress may slow the advance of numerous age-related diseases. Today, there are many genes that have been identified in certain insects, which, when manipulated, lead to an increase in lifespan in insects. Of those tested, all provide

an increased resistance to oxidative stress as a means of modifying lifespan. In addition, the lifespan can also be extended by the administration of synthetic superoxide dismutase (SOD) as it also appears to provide resistance to oxidative damage. An interesting study in insects demonstrated that when SOD-producing genes were inserted into cells of fruit flies it caused them to produce even more SOD, resulting in a 40% extension of life. In a human study, findings suggested that increased SOD activity in certain populations resulted in better protective mechanisms against aging effects. Research with GliSODin® clearly demonstrates that it can protect the cell from genetic damage caused by oxidative stress while boosting total cellular defense – all critical in diminishing the aging effect in cells. GliSODin® is the first vegetarian SOD that has been shown to be orally bioactive.* Carl Germano, R.D., C.N.S., L.D.N 



Based on the antigenic nature of vegetal SOD, the GliSODin® complex induces adaptive systems of redox regulation and immuno-modulation. 



Quality of Life:


GliSODin® complex is being actively investigated to clarify the strong indications that it can help alleviate a wide range of symptoms linked to cellular inflammation. GliSODin® is also being studied to follow up on indications that its consumption may help slow the cellular aging process. 



Priority Management:


While conventional medicine generally acts to alleviate specific symptoms, the GliSODin® product maintains its general ability to promote tissue health and reduce the damage to certain injured vital organs, notably the liver.



Individuality of Dose:


The dosing of GliSODin® depends on the clinical status of the subject. The base dose is the equivalent of 100 IU SOD per day and may be increases if necessary to 500 IU SOD per day. GliSODin® has a very low toxicity.



GliSODin versus usual anti-oxidant drugs:


As a dietary supplement, GliSODin® is unique in that it is a natural extract that can regulate production of anti-oxidant enzymes and molecules in the body. GliSODin® is a natural detoxifying enzyme that promotes natural defenses of the organism.



Benefits from using the GliSODin® product:


Chronic, infectious, inflammatory, degenerative and cancer tax the body energy stores and immune capacities. GliSODin® replenishes the energy needed to enhance the natural defense system and alleviate symptoms of cellular stress.
The daily pressures of life, noise and environmental pollution, and other stresses pose a cumulative harmful health threat that may contribute to the onset of disease. GliSODin® has been reported to reduce the effects of stress-induced free radical production.